Philadelphia, PA
P-Shot
What is the P-Shot?
The P-Shot is an injection of platelet-rich plasma — a concentrate made from your own blood — into the erectile tissue of the penis. The rationale is that growth factors released by platelets promote new blood vessel formation and tissue repair, addressing a cause of erectile dysfunction rather than only its symptoms, which is what PDE5 inhibitors such as Viagra and Cialis do.
It is performed by Dr. Ghavami in private, with no downtime. Numbing is done in two stages — topical anesthetic first, then subcutaneous lidocaine, which the physician administers himself. The injected step is the one nobody puts in the brochure: it stings, briefly and properly, and we would rather you know that before the appointment than during it.
What does the evidence actually show?
Here is where we part company with most clinics offering this treatment: the honest answer is that it is not settled.
Individual randomized trials have reported improvement in erectile function scores, including a double-blind placebo-controlled trial of 60 men with mild to moderate erectile dysfunction. But a 2026 meta-analysis pooling the randomized evidence concluded that PRP does not produce a consistent, clinically meaningful improvement over placebo, and that small sample sizes and methodological limitations across the trials limit confidence in either direction.
The professional bodies have not endorsed it. A 2026 systematic review in the World Journal of Men’s Health concluded that no firm recommendations can yet be drawn about the effect of penile PRP, and reported that the European Association of Urology’s own guidelines state further study is needed before PRP and stem cell therapy can be recommended. The trials that exist vary widely in the volume of plasma used, the number of injections and their timing — which is part of why the results are hard to reconcile.
What is reasonably consistent across the trials is safety: no significant adverse events have been reported, which is what you would expect from a preparation made from your own blood.
So: a plausible mechanism, mixed results, and no professional body endorsing it yet. If a clinic tells you it is proven, they have not read the literature.
Which leaves the decision where it belongs — with you. We have patients who chose to try it and report a favorable outcome, and we take that seriously without mistaking it for trial evidence. If you want to go ahead having read the above, we will perform it properly and tell you honestly what to expect.
Why we evaluate before we inject
Erectile dysfunction is frequently the first visible sign of something else. Vascular erectile dysfunction can precede a cardiac event by years, and it is also associated with diabetes, high blood pressure, low testosterone, sleep apnea, depression and the side effects of common medications.
Injecting PRP without asking why you have erectile dysfunction is poor medicine. Because we are a physician practice with primary care and wellness under the same roof, a consultation here means an actual history, an examination and blood work where indicated. If the answer turns out to be that your blood pressure, your testosterone or your metabolic health needs attention, we will tell you — and that may do more for you than any injection.
Where testosterone is the problem, testosterone replacement therapy is a properly evidenced treatment with a real diagnostic pathway behind it — and it is the conversation we would rather have with you than sell you a series of injections that will not address the cause.
Who is a candidate?
Men with mild to moderate erectile dysfunction who have been evaluated and who understand the state of the evidence. It is most often considered by men who cannot tolerate PDE5 inhibitors, who have had an inadequate response to them, or who would rather avoid a daily medication.
It is not a treatment for severe erectile dysfunction with established vascular disease, and it is not a substitute for treating an underlying cause.
What should I expect?
Forty-five to sixty minutes including preparation. We draw your blood, separate the platelet-rich fraction, numb the area with topical anesthetic followed by subcutaneous lidocaine, and inject. There is no downtime — most men return to normal activity the same day and to sexual activity within a few days.
Any improvement develops gradually over about four to twelve weeks rather than immediately.
Further reading
Why choose PhillyMedClub for the P-Shot in Philadelphia?
Because we evaluate before we inject. Injecting PRP without asking why you have erectile dysfunction is poor medicine, and a consultation here — a physician practice with primary care and wellness under the same roof — means an actual history, an examination and blood work where indicated. If the answer turns out to be your blood pressure or your testosterone, we would rather treat that than sell you a series of injections that will not address the cause. Dr. Ghavami performs the treatment privately, with numbing in two stages that he administers himself. And we will tell you plainly that not every man responds and that the pooled trial evidence does not show a consistent benefit over placebo — which is exactly why we discuss expectations before you decide. Private consultation, in Fishtown, Philadelphia.
PRP injected into erectile tissue, performed privately by a physician. The mechanism is plausible and the safety record in trials is good, but the evidence for benefit is genuinely mixed — we will walk you through what is known and what isn't before you decide.
Frequently asked questions
Who is a candidate for the P-Shot?
Men with mild to moderate erectile dysfunction who have been properly evaluated first, and who understand that the evidence for PRP is not settled. It is most often considered by men who cannot tolerate PDE5 inhibitors such as Viagra or Cialis, who have had an inadequate response to them, or who would rather not take a daily medication. It is not a treatment for severe erectile dysfunction with established vascular disease.
Is it painful?
Numbing is done in two stages — topical anesthetic first, then subcutaneous lidocaine, administered by the physician himself. The injected step stings briefly and properly, and we would rather tell you that in advance than have you discover it on the table. With the area numb, most patients describe the treatment itself as manageable.
How quickly do results appear?
If improvement occurs, it develops gradually over roughly 4 to 12 weeks rather than immediately. It is worth saying plainly that not every man responds, and the pooled trial evidence does not show a consistent benefit over placebo — which is why we discuss expectations carefully before you decide.
P-Shot
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